The present research aims at synthesis of diclofenac amino compounds, their corneal transport through mammalian cornea and characterization of screened compound. Four diclofenac amino acid compounds were synthesized named as Diclofenac Glycine compound (DGC), diclofenac histidine compound (DHC), diclofenac Arginine compound (DAC) and diclofenac lysine compound (DLC) and screened for in-vitro corneal transport through excised goat cornea using modified franz diffusion cell and also compared with 0.1% w/v diclofenac sodium aqueous solution (DS). DAC showed maximum transport through cornea. It was further characterized for physical properties, melting point, TLC, FTIR, DSC and XRD. The results suggested during synthesis process diclofenac free acid reacts with arginine and formed a complex having differed properties. The compound thus formed showed better permeation across cornea as compared to DS and physical mixture of diclofeanac and arginine and seems to show active transport phenomenon. Formation of amino acid compound of the diclofenac showed better permeability as compared to its corresponding salt.
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